"Ovulatory dysfunction" refers to a problem or irregularity in the process of releasing an egg from the ovary during a woman's menstrual cycle. It can lead to difficulties in getting pregnant or having regular periods. Full definition
«We treat those types of patients very simply, normally with clomiphene citrate, which is a pill that will normalize ovulation,» says Dr. Marrs, «If that doesn't work in certain cases of ovulatory dysfunction, women will take natural FSH, follicle stimulating hormone, and luteinizing hormone which are the two hormones in the pituitary gland that create ovulation within the ovarian follicle system.» (kidsinthehouse.com)
Similarly, in a rodent model of PCOS, levels of ERβ protein were decreased in the granulosa layers of cystic follicles.67 Idiopathic ovulatory dysfunction has been found to be associated with a G / A (1730) polymorphism in ERβ.2. (bioidenticalhormones101.com)
Given that ovulatory dysfunction is a key feature of PCOS, one group investigated a cohort of PCOS patients to determine if there was an association with this polymorphism.68 They reported significant differences in the genotype distribution and allelic frequencies between controls and PCOS patients that supported a correlation with the G / A polymorphism.68 To date, the underlying mechanism has not been established. (bioidenticalhormones101.com)