Your hunger and thirst are constantly depleting, while exploring the Dust gives you a depleting oxygen meter to worry about. (monstervine.com)
Also, keep an eye on your oxygen meter. (videochums.com)
The only annoyances come from certain menu elements when it comes to managing your item storage, as well as the AI constantly and endlessly reminding you to watch your health / oxygen meters. (newgamenetwork.com)