A recent study reported that two oxysterol species, 15HC and 15KC, were increased more than three-fold in the blood of multiple sclerosis patients, suggesting a potential use for these oxysterols as diagnostic biomarkers. (asbmb.org)
PPARγ appears to be part of a network of transcription factors coordinately regulating lipid uptake and cholesterol efflux in macrophages by transcriptionally regulating the scavenger receptor CD36 and the oxysterol receptor LXRα (liver X receptor α). (sbpdiscovery.org)
EBI2 (GPR183) is a Gαi coupled receptor that responds to the oxysterol ligand, 7α,25 - hydroxycholesterol (OHC)(Hannedouche et al., 2011; Liu et al., 2011). (elifesciences.org)