Citrate generated by glycolysis inhibits carnitine palmitoyltransferase complex I, limiting the beta - oxidation of fatty acids and thereby reducing ketogenesis. (nejm.org)
They cause an alteration in gene expression, leading to a suppression of key mitochondrial enzymes, like carnitine palmitoyltransferase — which finally solves the mystery of why those eating vegetarian have a 60 % higher expression of that fat - burning enzyme. (nutritionfacts.org)
Abbreviations: LDLR = LDL receptor; APOB / A1 = apolipoprotein B - 100 / A1; PCSK9 = proprotein convertase subtilisin / kexin type 9; SREBP - 1 / 2 = sterol regulatory element - binding protein 1/2; LPL = lipoprotein lipase; FATP2 / 4/5 = fatty acid transporter protein 2 / 4/5; FASN = fatty acid synthase; SCD5 = stearoyl - CoA desaturase 5; ACADL = acyl - CoA dehydrogenase; L - FABP = liver fatty acid - binding protein; and CPT1A = carnitine O - palmitoyltransferase 1. (clontech.com)