A partial agonist is a substance that only partially activates a receptor in the body, compared to a full agonist. It produces a weaker response or effect, as it doesn't fully engage the receptor. Full definition
In contrast, the second angiopoietin ligand, Ang2 acts as partial agonist of Tie2, that is, it inhibits Tie2 signalling in the presence of Ang1 and weakly activates Tie2 in the absence of Ang1 (ref. (nature.com)
The two «frontrunners», according to Dr. Buchanan, are ispronicline (nicotinic receptor partial agonist), and ORG 24448 (modulator of AMPA glutamate receptors). (schizophrenia.com)
Using sazetidine - A as a template, medicinal chemists developed multiple series of novel ligands with modifications to the pyridine core, azetidine ring, and alkynyl side chain with the objective of designing α4β2 - nAChR partial agonists of high specificity. (psychogenics.com)