"Pathological changes" refer to any abnormal or negative alterations that occur in the body or any living organism, which may be caused by disease, injury, or other harmful factors. Full definition
«The results suggest that such «master» regulatory factors could activate regions of the genome that are normally inactive, leading to the formation of organs during development, or the initiation of pathological changes in cells that lead to diseases such as cancer,» Taipale said. (ibtimes.com)
«Estrogen regulates pathological changes of bones via bone lining cells.» (sciencedaily.com)
In a nutshell toxicity can aggravate pre-existing conditions or cause pathological change in tissues (organs). (lyndagriparic.com)