The phrase "pathological hallmark" refers to a distinctive characteristic or feature that is commonly associated with a specific disease or condition. It is used to identify and define the illness or disorder. Full definition
Pathological hallmarks of AD, including plaques and loss of synaptic markers, are readily apparent at nine months of age in huAPP / PS1 mice along with clear deficits in spatial memory when compared to wild type controls [7, 10, 11, 31]. (alzres.biomedcentral.com)
Although these studies have addressed the temporal order in which AD pathological hallmarks appear, the exact sequence of cellular and molecular events that lead to AD is still poorly understood. (actaneurocomms.biomedcentral.com)
A research team led by Prof. Koji Yamanaka (Nagoya University) found that collapse of the MAM is a common pathological hallmark to two distinct inherited forms of ALS: SOD1 - and SIGMAR1 - linked ALS. (sciencedaily.com)