The profiling methods used in this research to identify molecular changes may be a general approach for differentiating the molecular pathology of disease models resulting from agent - specific effects, such as the effects of the two neurotoxins used in this research. (pnnl.gov)
«Using yeast genetics to identify a compound and its mechanism of action against the fundamental pathology of a disease illustrates the power of the system we've built,» says Lindquist, who is also professor of biology at MIT and a Howard Hughes Medical Institute investigator. (wi.mit.edu)
For Alzheimer's disease, the aim is for the investigational drug to target major pathologies of the disease and selectively activate a key receptor in the brain. (sciencedaily.com)