These data also suggest that different genetic events may lead to JAK - STAT pathway activation in different malignancies. (bloodjournal.org)
Further testing in human cells showed that methotrexate acts as a potent suppressor of JAK / STAT pathway activation — even in cells carrying the mutated gene responsible for MPNs in patients. (sciencedaily.com)
Wnt / ß - catenin signaling pathway activation reverses gemcitabine resistance by attenuating Beclin1 - mediated autophagy in the MG63 human osteosarcoma cell line. (abcam.com)