«Our work not only sheds light on UPR regulation, but demonstrates the physiological relevance of NMD's ability to regulate normal mRNAs.» (sciencedaily.com)
«The development of this microfluidic lung model, as well as other organs - on - chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator. (sciencedaily.com)
Human primary hepatocytes and immortalized cell lines (e.g., HepaRG) are used to study these disorders, but due to these cells» high variability, low availability, short assay window, or lack of physiological relevance, researchers studying metabolic diseases are searching for more robust and reliable models. (regmednet.com)