Resistance to artemisinin in parts of Southeast Asia is well - documented, but until now only a few studies have presented clear evidence of piperaquine resistance. (sciencedaily.com)
The findings also provide evidence to initiate surveillance programs to track the spread of piperaquine resistance and clinical trials to test alternative combination therapies. (sciencedaily.com)
These findings informed new WHO guidelines reinstating artesunate plus mefloquine as the first - line ACT in Cambodia where dihydroartemisinin - piperaquine treatment has failed. (sciencedaily.com)