Angiotensin II increases the intracellular calcium activity in podocytes of the intact glomerulus. (nature.com)
A team led by Donald Ingber, Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and Founding Director of Harvard's Wyss Institute of Biologically Inspired Engineering, now reports a solution to this challenge in Nature Biomedical Engineering, which enables the differentiation of human induced pluripotent stem (iPS) cells into mature podocytes with more than 90 percent efficiency. (seas.harvard.edu)
This was followed by postdoctoral work at Children's Hospital Los Angeles, California, in which Dr. Da Sacco focused his research on the differentiation of the previously identified renal progenitors into podocyte - like cells. (sciencemag.org)