We demonstrated that ABL kinases promoted tumor - induced osteolysis in part through the osteoclast - activating cytokine IL - 6, increased serum concentrations of which are associated with poor clinical outcome in breast cancer patients (50). (stke.sciencemag.org)
In addition, higher REV - ERBα expression or lower BMAL1 expression both predict poor clinical outcome for human neuroblastoma patients, as determined by publicly available patient survival data from The Children's Hospital of Philadelphia and the University of Cologne, Germany. (sciencedaily.com)
Shalowitz and colleagues suggest future studies should focus on defining areas with poor clinical outcomes attributed to geographic factors, and creating a comprehensive national, geographically - linked database on the utilization of gynecologic cancer care and clinical outcomes. (sciencedaily.com)