DAXX expression correlated inversely with expression of positive regulators of autophagy, including DAPK1, DAPK3, ATG8, ATG18, ATG101, LC20, ATG3, ATG4, Beclin1, ATG7 (Figure 5), and Deptor (not shown), whereas it correlated positively with expression of negative regulators of autophagy, mTOR and Raptor (Figure 6A and 6B). (impactjournals.com)
Dr. Sharpe's functional analysis of costimulatory pathways regulating T cell activation has led to understanding of (1) the roles of B7 - 1 and B7 - 2 as positive regulators through CD28 and (2) negative regulators through CTLA - 4, and (3) the role of PD - L1 and PD - L2 as negative regulators through PD - 1. (warrenalpert.org)
Now, new research from the laboratory of Vaijayanti P. Kale (National Centre for Cell Science, Pune, Maharashtra, India) has described a fascinating new approach to return lost functionality to aged mouse HSCs: the transfer of microvesicles (MVs) containing positive regulators of autophagy derived from young mesenchymal stem cells (MSCs)[6]. (stemcellsportal.com)