The Polonis lab has also employed both cell line - based model systems, as well as primary cell types from uninfected humans, to investigate virus - antibody - host cell interactions and cross-subtype reactivities amongst the major subtypes of the HIV pandemic. (hivresearch.org)
Allogeneic cell therapies involving primary cell types such as bone marrow mesenchymal stromal / stem cells (BM - MSCs), hematopoietic stem and progenitor cells (HSPCs), and T and natural killer (NK) cells for immunotherapy applications are especially challenging because of the vigorous process of screening... (bioprocessintl.com)
Future experiments using iPSCs reprogrammed by the episomal virus - free, transgene - free strategy, in different original primary cell types is needed to validate such hypothesis. (journals.plos.org)