Although important for initiating inflammatory responses to bacteria, continued production of this chemical can damage tissue. (newscientist.com)
Apparently, cannabis and its compounds can inhibit immune system pro inflammatory (and pro acne) chemicals directly and promote production of chemicals which regulate the immune system. (supernaturalacnetreatment.com)
The difference has to do with cells in the body that respond to allergens by production of a chemical called histamine. (happytailsspa-blog.com)