Here, too, are episodes of profound suffering and loss, ambition and conviction, courage and love. (booklistonline.com)
For the next 11 years, Mother Teresa would undergo profound suffering and confusion at the loss of the intimacy of Jesus and the consolations of prayer. (premierchristianity.com)
However deep and profound our suffering, «the Fates have given mortals hearts that can endure.» (firstthings.com)