Anti-angiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis (cancerres.aacrjournals.org)
Defects in cell death mechanisms represent one of the six identified cardinal features of cancer [12], and are commonly associated with progression of tumors to refractory, chemoresistant disease [13]. (impactjournals.com)
A critical hallmark of the malignant progression of tumors is evasion and suppression of the immune system. (sciencedaily.com)