This is known to be a congenital, hereditary progressive kidney disease in certain breeds, whereby the kidneys do not maintain sufficient function to sustain life. (k9web.com)
The work, inspired by an investigation into a genetic form of the condition, has the potential to affect therapeutic research for millions of people suffering from progressive kidney diseases. (sciencedaily.com)
The researchers predicted that the TRPC5 mechanism might play a similar role in other types of progressive kidney disease — even if, in those cases, the damaging feedback loop was kickstarted from chronic disorders such as high blood pressure, rather than a specific genetic mutation. (sciencedaily.com)