Lethal toxin is a well - characterized two - subunit bacterial toxin from B. anthracis comprised of protective antigen and lethal factor [31, 32]. (journals.plos.org)
The ILCs present in Rag1 - / - splenocytes bound protective antigen in a dose - dependent manner (S1C Fig), suggesting the cells were direct targets for lethal toxin. (journals.plos.org)
Recombinant protective antigen and wild - type lethal factor or lethal factor mutant (E687C) were obtained from List Biologicals (Campbell, CA) or BEI Resources (Manassas, VA). (journals.plos.org)