The main molecular alterations are represented by variations in gene expression, usually mild and with consequences for a vast number of target protein coding genes. (mdanderson.org)
Using data from experiments that simultaneously measure the effects of thousands of mutations, I develop computational tools to predict the functional impact of mutations in protein coding sequences. (cshl.edu)
The number human protein coding genes, which account for less than 2 % of the human genome, have recently been found to number over 20,000. (sciencedaily.com)