Osteocalcin, secreted by osteoblasts, is a non-collagenous protein hormone responsible for bone mineralization, ionized calcium homeostasis, insulin sensitivity, and testosterone biosynthesis. (microbiomelabs.com)
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Friedman's group was able to track down the mutation in the obese mice and found that it blocked production of a particular protein hormone, which they named leptin. (scientificamerican.com)