The principle of proteolysis in vivo is to instigate irreversible changes to a set of protein substrates that alters their function and generates the required biological event. (sbpdiscovery.org)
I feel that you do not adequately cover protein - protein or protein substrate interactions in the proposed IRG list. (sciencemag.org)
PRMTs also interact with multiple protein substrates, so there are many projects to work on. (sbgrid.org)