Some of these conditions can be corrected by education; none of them can be corrected by reducing the number of puppies produced by responsible breeders. (canismajor.com)
Puppy mill breeding dogs are often given hormones and steroids to try and increase the number of puppies they produce. (animalrescuecorps.org)
On average, 50 % of such a litter will be clear and 50 % carriers; there can be no affected puppies produced from such a mating. (vetgen.com)