"Radical reorientation" refers to a significant and dramatic change in direction or focus. It involves a complete shift from the old ways of thinking or doing things towards a completely different approach or perspective. Full definition
Yet Pollock's radical reorientation of time in painting - his concentration on the instant at which the paint hit the canvas, purging references to past time or previous painting - was the central inspiration for the immediacy in the gestural painting of the fifties as well as in the «happenings» that began at the end of the decade. (visual-arts-cork.com)
In Hobbes, Owen finds «not unbelief, but a radical reorientation of human concerns to goods of this life.... (firstthings.com)
Suffice it to say that implicit in the novel's conclusion is the understanding of confession articulated in the Catechism of the Catholic Church, which declares that «Interior repentance is a radical reorientation of our whole life, a conversion to God with all our heart, an end of sin, a turning away from evil, with repugnance toward the evil actions we have committed.» (firstthings.com)