The third paper in the issue of the Journal of Clinical Oncology describes an analysis of a very rare subset of patients with low - stage disease and amplification of the MYCN oncogene. (uchospitals.edu)
Using genetic tools to establish in which cells cancer - driving mutations originated and then propagated into other cancer cells, they demonstrated that a distinct and rare subset of MDS cells showed all the hallmarks of cancer stem cells, and that no other malignant MDS cells were able to propagate the tumour. (sciencedaily.com)
This analysis suggests that a rare subset of tumor cells harbor different genetic alterations and that those cells serve as the seeds for the recurrence of rhabdomyosarcoma.» (sciencedaily.com)