But finding greater rates of mutations in children born to the older mothers did come as a surprise. (sciencedaily.com)
Now called APR - 246, in 2012 it made it through the first round of safety trials on patients with a type of blood cancer that shows high rates of mutations in p53. (sciencemag.org)
Please keep in mind that dam - / dcm - strains may have an increased rate of mutation (as these would also be deficient in mis - match repair functions of Dam), so these strains should not be used for long term storage. (blog.addgene.org)