First - line combination therapy with the programmed death ligand 1 (PD - L1) inhibitor avelumab and the vascular endothelial growth factor receptor tyrosine kinase inhibitor axitinib resulted in encouraging antitumor activity in patients with previously untreated renal cell carcinoma (RCC) and had a manageable toxicity profile, according to the results of the JAVELIN Renal 100 study published in Lancet Oncology. (cancernetwork.com)
To further assess the effect of Tie2 in pericytes on EC - pericyte intercellular signalling, we performed a phospho - receptor tyrosine kinase array of BP and HUVEC co-cultures. (nature.com)
Ari Hashimoto and colleagues found that the MVP promotes the recruitment of Arf6 to the plasma membrane, where it can be activated by receptor tyrosine kinases. (sciencedaily.com)