One of the surprising findings coming out of large cancer re-sequencing studies, such as The Cancer Genome Atlas (TCGA), was the large number of recurrent mutations in transcriptional regulators and chromatin remodeling enzymes. (vicc.org)
This analysis led to the identification of recurrent mutations in a specific gene, called NFKBIE, which encodes a protein involved in the NF - kB signalling pathway. (scilifelab.se)
Okosun J, Bödör C, Wang J, Araf S, Yang CY, Pan C, Boller S, Cittaro D, Bozek M, Iqbal S, Matthews J, Wrench D, Marzec J, Tawana K, Popov N, O'Riain C, O'Shea D, Carlotti E, Davies A, Lawrie CH, Matolcsy A, Calaminici M, Norton A, Byers RJ, Mein C, Stupka E, Lister TA, Lenz G, Montoto S, Gribben JG, Fan Y, Grosschedl R, Chelala C, Fitzgibbon J. Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma. (research.hsr.it)