U-M has been a pioneer in using MIBG as targeted therapy for patients with refractory disease since the therapy's origins at U-M more than two decades ago. (mottchildren.org)
«High levels of the cell signalling protein TNF have been reported in JDM patients with a long disease course, suggesting this immune cell regulator may play a significant role in refractory disease,» said Dr Raquel Campanilho - Marques of the Institute of Child Health, University College London, UK. (sciencedaily.com)
• Subject is in second or later hematologic relapse or has received salvage therapy for refractory disease • Subject has clinically active central nervous system leukemia. (vicc.org)