Jia - Jiun Yan (Antos, TUD)-- «Identification of regulatory domains that determine the subcellular distribution of the protein Simplet» (2014) (dresden-ipp.de)
To quote the researchers: «Thus, modification of this PIP2 regulatory domain by genetic, biochemical, or pharmacological mechanisms may have profound effects on sensitivity of primary afferent nerve fibers to chemical and thermal stimuli under normal or pathological conditions.» (fieryfoodscentral.com)
A tetramer of two regulatory domains forms a gating ring that regulates calcium ion activation. (science.sciencemag.org)