In these circumstances, the DNA can not replicate itself naturally, generating replication stress, mutations and chromosome mutations. (sciencedaily.com)
However, we have found that loss of 53BP1 also results in DNA replication stress and this provides a new avenue for treating those cancers that have acquired these mutations. (ccri.uthscsa.edu)
CFSs now appear as preferential targets for oncogene - induced replication stress in precancerous lesions, which suggests that their instability promotes oncogenesis from early stages of the process. (science.institut-curie.org)