We studied 11 Alaskan Husky dogs with AHE, but found no abnormalities in respiratory chain enzyme activities in muscle and liver, or mutations in mitochondrial or nuclear genes that cause LS in people. (vetmed.ucdavis.edu)
The team also found that DHODH binds a particular kind of lipid present in mitochondrial respiratory chain complex, an important system for cellular energy production. (scilifelab.se)
The optimized allotopic expression of ND1 or ND4 genes restores respiratory chain complex I activity in fibroblasts harboring mutations in these genes. (sens.org)