A novel mechanism involving omega - 3 modulation of cAMP response element binding protein (CREB) and brain - derived neurotrophic factor (BDNF) is proposed. (chiro.org)
Sustained activation of nuclear erythroid 2 - related factor 2 / antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice. (abcam.com)
Specifically, Sceletium tortuosum works by dual 5 - HT reuptake inhibition and PDE4 (phosphodiesterase subtype 4) inhibition which plays a crucial role in regulating cognition via the PDE - 4 - cAMP cascade signaling pathway involving phosphorylated cAMP response element binding protein (CREB). (olympus-labs.com)