Instead, remote mutations change interactions such as salt bridges and hydrogen bonds significantly over the evolutionary pathways. (cen.acs.org)
«NMR enabled us to obtain additional information such as which amino acid residues form salt bridges thus enhancing the stability of the fibrils,» explains Prof. Henrike Heise from Heinrich Heine University Düsseldorf and Jülich's Biomolecular NMR Center. (sciencedaily.com)
While Class I binds via interactions mediated by backbone hydrogen bonds, Class II uses a pair of arginine residues to establish salt bridges to its ATP ligand. (journals.plos.org)