Simparica contains the active ingredient sarolaner, which inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. (1800petmeds.com)
Evaluation of the speed of kill, effects on reproduction, and effectiveness in a simulated infested - home environment of sarolaner (Simparica ™) against fleas on dogs. (winslowanimalhospital.com)
Some of these oral medications include milbemycin (the active ingredient of Interceptor ® and Sentinel ®), afoxolaner (NexGard ®), fluralaner (Bravecto ®), and sarolaner (Simparica ®). (brittonroadveterinaryclinic.com)