Cells along the continuum show a progressively decreasing likelihood of self renewal as their expression of stem cell surface markers and pluripotency genes wanes. (journals.plos.org)
Perform RNAi screens in mouse ES cells to identify and characterize factors involved in self renewal and differentiation, (dresden-ipp.de)
During embryonic development, neurogenesis proceeds maintaining a fine balance between mechanisms that support self renewal of undifferentiated radial progenitors and others that instruct precursors to commit to specific fates and achieve terminal differentiation. (eurosystemproject.eu)