Individuals with epileptic encephalopathy caused by mutations in DENND5A present with serious anomalies in brain structure along with calcifications in the brain and altered facial features. (sciencedaily.com)
He laid out this structure with great care: normal science (routine scientific work), with its specific accompanying paradigm and a dedication to solving puzzles; followed by serious anomalies produced by research, which lead to a crisis; and finally resolution of that crisis by the creation of a new paradigm. (newscientist.com)
This is a long overdue investigation into a very serious anomaly in UK constitutional law. (politics.co.uk)