The best science shows that PMS is the result of the poorly synchronized dance between four entities: progesterone, allopregnanolone (a derivative of progesterone), and the GABA and serotonin pathways in the brain, which make you calm and happy. (saragottfriedmd.com)
Lithium influences serotonin pathways, and numerous people have noted that it has helped them feel calmer and less angry without feeling sedated. (drlaurell.com)
About 20 to 30 percent of women are sensitive to estrogen and need it to bolster their mood and prevent depression, which is possibly related to serotonin pathways in the brain that are connected to mood, sleep, and appetite. (saragottfriedmd.com)