In many immune cells, lethal toxin turns off signaling events through degradation of intermediate signaling components. (journals.plos.org)
The image is an example of signal components at a frequency of 1 - 5 Hz. (sciencedaily.com)
What I'm saying is that the strictly linear MATHEMATICAL operation of integration — continuous or discrete — can not produce signal components at frequencies other than those already present in the signal. (wattsupwiththat.com)