Indeed, the most exhaustive research I know on how land use affects travel behavior found that location — measured by, among other things, the distance from the regional center — is by far the most significant determinant of how much household driving will occur, over time, from a given location. (treehugger.com)
However, «The test score measure is structured so it becomes the most significant determinant in a teacher's overall rating. (vamboozled.com)
China's coal consumption has become the single most significant determinant for the future of the world's climate. (dotearth.blogs.nytimes.com)