The phrase "significant handicap" means having a major disadvantage or limitation that makes it difficult to do certain things compared to others. Full definition
If eve came from Adams rib, they would share DNA (logically Adam's rib would have been Adams clone, not Eve, but disregarding logic as one must in such cases) therefore the relationship would be incestuous and would create humans with significant handicaps and disabilities, if anything at all. (religion.blogs.cnn.com)
The i30's most significant handicap is its short history. (drivemag.com)
And I have two siblings who were born with significant handicaps. (scientificamerican.com)