And in both cases, there are massive and significant limits on the independence of the medical profession — either from direct pay or from the insurance companies or health management organizations. (slaw.ca)
But first - generation systems had significant limits in how they had to be trained and in their ability to handle the real - world problems of e-discovery. (catalystsecure.com)
The most significant limiting factor by far in this game how much tedium the player can physically stand. (medium.com)