The phrase "significant risk" means there is a possibility of something bad or harmful happening that could have important or major consequences. Full definition
Lack of sufficient physical activity places children and young people at significant risk of developing diseases such as diabetes, cancer and heart disease. (educationmattersmag.com.au)
But for pregnant women, the virus poses significant risks for their developing baby. (health-and-parenting.com)
This funding aims to improve population level early childhood developmental health outcomes in a state with significant risk factors for poor child health status. (mchb.hrsa.gov)