The phrase "single mutation" refers to a change or alteration in a single part of our genetic code, which is responsible for our inherited traits and characteristics. Full definition
If age of onset of the disease varies, hold off breeding dogs with single mutations until they are past the average age of onset, if at all possible. (ashgi.org)
Some genetic insults can cause breaks in the DNA, while others introduce single mutations - changes in the sequence of letters in DNA. (en.hdbuzz.net)
With current techniques it is not easy to make comparative analysis of influenza viruses with single mutations in their genomes, and it is extremely difficult to identify factors that limit the reassortment process between two influenza genomes that have infected the same cell. (sciencedaily.com)