Ovarian cancer is difficult to treat because it's not often diagnosed until it has already metastasized to the peritoneum, liver or lung, the most common sites of metastasis according to the National Cancer Institute. (sciencedaily.com)
Malanchi and colleagues show that POSTN is expressed primarily in fibroblasts and to a lesser extent in endothelial cells but is not expressed in immune cells at sites of metastasis (Malanchi et al., 2012). (elifesciences.org)
They could also image the various final destinations of individual circulating cells and observe how these cells travel through circulation and colonize healthy tissue, existing sites of metastasis, or the site of the primary tumor. (sciencedaily.com)