Many modern opioid - based painkillers don't target the specific site of pain but instead interfere with the brain's sensation of that pain. (newatlas.com)
But now I would also say that sometimes the only way out of pain is to embrace the site of the pain as the very site of the healing. (sarahbessey.com)
Our knowledge of the neural pathways that underlie behaviour has allowed us to search for the site of pain in these animals, but it is still unclear. (newscientist.com)