These procedures generate animals that carry specific genetic alterations, and recreate the underlying cause of a human disorder or uncover the role of any gene of interest. (laskerfoundation.org)
Parkinson contends that targeted gene replacement produces cells having specific genetic alterations far more effectively than the traditional technique for making transgenic animals, which entails injecting DNA into cell nuclei. (scientificamerican.com)
Patients whose melanoma tumors do not have BRAF alterations will have other specific genetic alterations identified and these changes will be matched to an appropriate therapy that directly targets those alterations. (standuptocancer.org)