His uses genome engineering methods to test the role of specific genetic changes in induced pluripotent cell (iPSC)- derived models of disease. (gladstone.org)
Interspecies comparison and the introduction of specific genetic changes in short - and long - lived model organisms are used to delineate genetic factors influencing the aging process. (fli-leibniz.de)
But determining which specific genetic changes led to humans won't be easy, says Asao Fujiyama, of RIKEN Genomic Sciences Center and the National Institute of Informatics in Japan, one of the project leaders: «The key proteins are very difficult to iron out because we have so many differences.» (discovermagazine.com)