By means of their mouse model, the hormone researchers from Ulm could prove that dexamethasone — mediated through the dimer function of GR — leads to the release of sphingosine -1-phosphate in the macrophages, a tissue hormone that fosters growth, migration and division of cells and has a stabilization effect on inner vessel walls. (sciencedaily.com)
Nagahashi M, Takabe K, Liu R, Wang Y, Hait NC, Wang X, Allegood JC, Yamada A, Aoyagi T, Liang J, Pandak WM, Cooper P, Spiegel S, Hylemon PB, and Zhou H. Conjugated Bile Acid Activated S1P Receptor 2 Is a Key Regulator of Sphingosine Kinase 2 and Hepatic Gene Expression. (roswellpark.org)
They found that sickle cell disease significantly increases S1P and that S1P is generated by sphingosine kinase 1 (SphK1). (sciencedaily.com)